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基于微生物组和聚类方法的急性辐射肠炎生物标志物的查

Chenying Ma¹, Xiaoting Xu¹, Songbing Qin¹

¹Department of Radiation Oncology, the First Affiliated Hospital of Soochow University, Suzhou, 215006, China.

BMC microbiology

|November 8, 2024

概括

肠道微生物群的肠道类型,特别是Faecalibacterium和Escherichia-Shigella,可以预测癌症患者的严重急性辐射肠炎 (SARE). 肠型分类显示出作为放射治疗期间SARE风险的生物标志物具有前途.

科学领域:

微生物组研究的研究.
在瘤学瘤学.
胃肠病学胃肠病学

背景情况:

放射性肠炎 (RE) 是一种常见的放射治疗并发症,影响患者的生活质量.
肠道微生物组的改变与RE的病原发生有关,但具体因素尚不清楚.
这项研究调查了RE和严重急性辐射肠炎 (SARE) 的微生物变化,以找到预测性生物标志物.

研究的目的:

描述与RE和SARE相关的肠道微生物转移.
确定在接受放射治疗的癌症患者中SARE发展的潜在预测生物标志物.

主要方法:

16S rDNA测序和生物信息学分析便样本.
在放射治疗期间从50名宫癌患者和15名健康对照组中采集的样本.
在基线,治疗第2,4周和第6周的纵向样本采集.

主要成果:

单独的细菌体/细菌体 (B/F) 比率并不能预测RE或SARE.
发现了三种肠类型:蓝病,埃舍里希亚-希格拉和菌.
降低蓝皮病和增加埃舍里希亚-希格拉和便细菌与RE/SARE相关.
发病时的便细菌肠型与4.4倍的SARE风险增加有关 (OR 5.400,P=0.017).
埃舍里希亚-希格拉肠型也与较高的SARE发病率有关.

结论:

单个细菌属或B/F比不足以预测SARE.
肠型分类显示了作为SARE预测生物标志物的潜力.
对放射治疗引起的肠炎的基于肠型的生物标志物的进一步验证是有必要的.

关键词:

生物标志物生物标志物宫癌是发生在宫癌的原因之一.聚类方法聚类方法肠道屏障肠道屏障肠道屏障微生物组是一个微生物组.辐射肠炎是一种辐射肠炎.

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