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超过狗过敏原皮肤试验与乙沉和传统狗相比:一项回顾性研究

Joshua Pollock1, Nora Watson2, Luke Pittman1

  • 1From the Department of Allergy and Immunology, Walter Reed National Military Medical Center, Bethesda, MD and.

Allergy and asthma proceedings
|November 9, 2024
PubMed
概括

超过 (UF) 狗狗提取物在通过皮测试 (SPT) 检测狗的敏感性方面表现出与乙沉 (AP) 狗狗提取物相似的疗效. 与传统狗狗提取物相比,UF狗狗提取物还显示出更好的稳定性和更高的阳性率.

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Toxicity Testing in Animals01:23

Toxicity Testing in Animals

Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...