硫化减轻神经退化,可能是通过减少氧化应激和阿尔多减少酶表达来减轻神经退化
Wenqi Shen1, Tingyu Hu2, Xin Wang2
1Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, China.
Journal of cellular and molecular medicine
|November 9, 2024
概括
硫化 (H2S) 疗法通过减少氧化应激和阿尔多减少酶,改善了糖尿病大鼠的神经损伤. 这种治疗显示出在不影响血糖的情况下管理糖尿病外围神经病变的潜力.
科学领域:
- 生物医学科学 生物医学科学
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 糖尿病外围神经病变是一种糖尿病的常见并发症.
- 氧化应激和阿尔多减少酶的上调有助于糖尿病神经损伤.
研究的目的:
- 研究硫化 (H2S) 作为糖尿病外围神经病变的潜在治疗方法.
- 评估H2S对氧化应激和神经退化在老鼠模型中的影响.
主要方法:
- 糖尿病老鼠模型是使用链毒素建立的.
- 两周内,老鼠每天都会通过腹膜内注射二硫化 (H2S).
- 神经功能,组织学和生物化学标记被评估,使用包括电肌学,显微镜,西部斑点和ELISA在内的技术.
主要成果:
- H2S治疗没有改变体重,血糖或肝功能.
- 施用H2S减少了神经元的损失,背部根的细胞缩,以及坐骨神经轴突退化.
- H2S疗法恢复了血清中超氧化脱酶 (SOD) 水平和坐骨神经的SOD2表达,同时降低了甲和阿尔多减少酶.
结论:
- 硫化可以缓解糖尿病老鼠的神经退行.
- H2S的治疗效果很可能通过减少氧化应激和降低阿尔多减少酶表达的调节来调节.
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