在接受腹腔透析的患者中,药物治疗方案的复杂性和以患者为中心的结果
Jing Xin Goh1, Kamal Sud2,3, Wubshet Tesfaye4
1School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia.
Healthcare (Basel, Switzerland)
|November 9, 2024
概括
腹腔透析 (PD) 的患者往往需要复杂的药物治疗. 患PD患者的药物坚持与更好的健康相关生活质量和改善血清酸盐水平有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 患者的治疗结果.
背景情况:
- 腹腔透析 (PD) 患者有复杂的治疗需求.
- 药物治疗方案复杂性对PD患者结果的影响需要进行彻底评估.
研究的目的:
- 为了量化PD患者的药物治疗方案复杂性.
- 评估以患者为中心的结果,包括药物坚持及其决定因素,在PD患者中.
主要方法:
- 结合了回顾性和前性研究设计.
- 使用65项药物治疗方案复杂性指数 (MRCI) 评估了药物治疗方案的复杂性.
- 用经过验证的问卷来评估患者的结果:莫里斯基-格林-莱文尺度 (MGLS),EQ-5D-5L和EQ VAS.
主要成果:
- 131名PD患者参与,平均MRCI得分为28.6±11.4,表明复杂的治疗方案.
- 60.3%的参与者 (n=79) 坚持每MGLS的药物治疗.
- 不遵守与男性性别,高血清酸盐和较低的健康相关生活质量 (HRQoL) 相关.
结论:
- 患有PD的患者在透析治疗的同时面临复杂的药物治疗方案.
- 在PD患者中,药物坚持与更好的HRQoL和血清酸盐水平显著相关.
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