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-合金:对于可生物降解的生物医学植入物来说是一个有前途的解决方案

Sachin Kumar Sharma¹, Sandra Gajević², Lokesh Kumar Sharma³

¹Surface Science and Tribology Lab, Department of Mechanical Engineering, Shiv Nadar Institute of Eminence, Gautam Buddha Nagar 201314, India.

Materials (Basel, Switzerland)

|November 9, 2024

概括

- (Mg-Ti) 合金为可生物降解的医疗植入物提供了更好的生物相容性和耐腐蚀性. 这些合金对临时的骨科应用有希望,减少了切除手术的需要.

科学领域:

生物材料科学生物材料科学
材料工程材料工程材料工程
整形外科的研究研究.

背景情况:

(Mg) 是一个有前途的可生物降解的植入物材料,由于生物相容性和减少应力屏蔽.
快速降解和较差的耐腐蚀性限制了Mg在生理条件下的使用.
将 (Ti) 整合到Mg中可以提高机械和腐蚀性能.

研究的目的:

研究- (Mg-Ti) 合金作为医疗植入物的先进生物降解材料的潜力.
评估添加对基合金的性能和性能的影响.
探索Mg-Ti合金在临时骨科植入物中的应用.

主要方法:

使用机械合金和火花等离子烧结 (SPS) 来制造Mg-Ti合金.
在模拟的体液中评估了耐腐蚀性,重点是Mg80-Ti20成分.
使用骨质前细胞评估了细胞毒性.

主要成果:

火花等离子烧结 (SPS) 生产了批量Mg-Ti材料,具有增强的结构完整性和耐腐蚀性.
Mg80-Ti20合金在模拟的体液中表现出优越的耐腐蚀性.
在对骨质前细胞进行测试时,Mg-Ti合金没有显著的毒性.
形成了含有多乳糖合糖酸 (PLGA) 的复合物,调节了降解和pH稳定性.

结论:

Mg-Ti合金为克服生物医学应用中纯的局限性提供了一个可行的解决方案.
这些合金适用于临时的骨科植入物,在骨折愈合期间提供承载支持.
建议对巩固方法和腐蚀与机械负荷之间的相互作用进行进一步的研究,以获得更广泛的临床应用.

关键词:

滚球磨砂机 - 滚球磨砂机可生物降解,可生物降解.腐蚀腐蚀是一种腐蚀.的含量是多少? 的含量是多少?在火花等离子烧结过程中,火花等离子烧结.

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