植物衍生生物活性化合物的分子标在口腔状细胞癌中的分子标
Gabriela Mitea1, Verginica Schröder2, Irina Mihaela Iancu3
1Department of Pharmacology, Faculty of Pharmacy, Ovidius University of Constanta, 900470 Constanta, Romania.
Cancers
|November 9, 2024
概括
天然草药产品作为口腔癌的补充疗法具有前景,可能增强传统治疗方法并减少副作用. 对这些天然化合物的进一步研究可能会导致更安全,更有效的口腔癌治疗方法.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 口腔癌,特别是口腔状细胞癌 (OSCC),是一个重大的全球卫生挑战,死亡率高,特别是在发展中国家.
- 像手术,化疗和放射治疗这样的传统治疗方法提供了有限的生存改善,通常是由于晚期诊断和转移.
- 现有疗法也可能导致严重的副作用和耐药性,需要探索替代方法.
研究的目的:
- 审查天然草本产品作为口腔癌辅助疗法的治疗潜力.
- 在临床前模型中探索自然化合物的分子机制和疗效.
- 确定战略管理方法,以优化这些天然剂在临床环境中的使用.
主要方法:
- 包括PubMed,科学网络,谷歌学者,Scopus和Elsevier在内的在线数据库的全面文献搜索.
- 分析研究,调查用于治疗口腔癌的天然草药产品的研究.
- 评估体外和体外模型,评估天然化合物的疗效和作用机制.
主要成果:
- 自然植物化合物在诱导亡,抑制瘤生长和增强化疗效方面表现出潜力.
- 自然化合物和传统疗法之间的协同效应是研究兴趣的一个关键领域.
- 研究强调了解分子机制和优化药物输送对于自然基的癌症治疗的重要性.
结论:
- 天然草药产品为传统的口腔癌治疗提供了一个有希望的补充策略.
- 这些天然化合物可能会导致开发更有效,更安全的癌症治疗方法,降低毒性.
- 本综述为瘤学界提供了见解,促进了口腔癌治疗方面的创新.
更多相关视频
12:03Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
Published on: July 25, 2011
19.2K
08:20Systematic Approach to Identify Novel Antimicrobial and Antibiofilm Molecules from Plants' Extracts and Fractions to Prevent Dental Caries
Published on: March 31, 2021
6.3K
相关概念视频
02:57Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
01:26Targets for Drug Action: Overview
6.0K
Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
6.0K
02:59Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
02:34Inhibition of Cdk Activity
4.7K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.7K