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甲状腺癌类型的PD-L1表达有所不同,并且与无进展生存率 (PFS) 降低的甲状腺癌患者有关

Leila Shobab¹, Deema Al-Souri¹, Liza Mathews-Kim²

¹Department of Medicine, Division of Endocrinology, MedStar Washington Hospital Center, Washington, DC 20010, USA.

|November 9, 2024

概括

编程死亡配体1 (PD-L1) 表达在甲状腺癌 (TC) 亚型中有所不同,并且与突变有关. 在无塑性TC (ATC) 中,PD-L1阳性与较短的无进展生存时间相关,这表明有针对性的免疫疗法的潜力.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
分子生物学分子生物学

背景情况:

甲状腺癌 (TC) 提出了重大的临床挑战,特别是抗治疗的侵袭性形式.
针对编程死亡配体1 (PD-L1) 的免疫检查点抑制剂在各种癌症中表现有前途,但它们在TC中的作用尚不清楚.
了解PD-L1表达对于开发用于高级TC的有效免疫疗法至关重要.

研究的目的:

在侵袭性甲状腺癌 (TC) 中调查编程死亡配体1 (PD-L1) 表达.
分析PD-L1表达与TC组织学亚型和分子突变的关联.
评估PD-L1状态对晚期TC无进展生存 (PFS) 的影响.

主要方法:

来自两个三级中心的176名晚期甲状腺癌患者的回顾性分析.
进行了瘤分子分析和PD-L1状态评估.
卡普兰-梅尔估计器被用来比较无进展生存期 (PFS) 基于PD-L1状态在无塑性TC (ATC) 亚组.

主要成果:

在TC类型 (p < 0.01) 中,PD-L1阳性差异很大,瘤细胞TC (71%) 和ATC (69%) 的频率最高.
TP53突变与PD-L1表达呈正相关,而RAS突变显示出负相关性.
在ATC小组中,积极的PD-L1表达与较短的PFS显著相关 (p = 0.002).

结论:

甲状腺癌中的PD-L1表达异质,受组织学类型和分子突变的影响.
在无塑性TC (ATC) 中的PD-L1表达与较差的无进展生存率有关.
需要对TC中PD-L1调节的分子机制进行进一步的研究,以指导个性化免疫治疗的开发.

关键词:

在甲状腺癌中的PD-L1表达.对于甲状腺癌的免疫治疗.放射性耐火材料放射性耐火材料甲状腺癌是一种癌症.甲状腺癌瘤微环境

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