HTCC及其纳米颗粒的双重抗菌活性:通过结合的体和体外研究,为抗菌和抗病毒应用采取协同方法
Khanyisile S Dhlamini1,2, Cyril T Selepe1,2, Bathabile Ramalapa1,3
1Centre for Nanostructures and Advanced Materials, DSI-CSIR Nanotechnology Innovation Centre, Council for Scientific and Industrial Research, Pretoria 0001, South Africa.
Polymers
|November 9, 2024
概括
N-(2-) -3-三甲基氨基基酸 (HTCC) 显示强烈的抗菌作用对金黄色葡萄球菌,但有限的抗病毒作用. 然而,HTCC纳米颗粒显示出抑制HIV-1病毒活动的显著潜力.
科学领域:
- 生物化学 生化学
- 材料科学 材料科学 材料科学
- 病毒学 病毒学
背景情况:
- 像N-(2-) -3-三甲氨基基托化物 (HTCC) 这样的四元化基托衍生物具有广泛的抗菌特性.
- 了解HTCC对细菌和病毒的原子级机制至关重要,但仍未得到充分研究.
研究的目的:
- 通过分子对接,研究HTCC对黄金葡萄球菌的抗菌活性和对HIV-1的抗病毒活性.
- 通过实验合成和体外检测验证计算发现.
- 探索HTCC纳米粒子 (NP) 在抗病毒应用中的潜力.
主要方法:
- 进行了分子对接分析,以预测HTCC与S. aureus和HIV-1的结合 afinities.
- 使用NMR,XRD,FTIR和DLS合成和表征HTCC衍生物.
- 在体外进行了针对S. aureus的抗菌试验和针对HIV-1的抗病毒试验.
主要成果:
- 分子对接表明HTCC对S. aureus的抗菌活性有希望,但对HIV-1的抗病毒活性有限.
- 实验验证证证实了HTCC在S. aureus的强烈的体外抗菌疗效.
- HTCC纳米颗粒在体外表现出显著的抗病毒活性对抗HIV-1,在0.33 mg/mL时达到100%的抑制.
结论:
- 通过计算和实验数据支持的HTCC对金黄色杆菌具有强大的抗菌特性.
- 虽然母HTCC聚合物对HIV-1的直接抗病毒活性有限,但HTCC纳米颗粒为开发新型抗病毒剂提供了有前途的战略.
- 对抗HIV-1的HTCCNP进行进一步的研究是有必要的,因为它们在纳米尺度上的性能优越.
更多相关视频
11:19Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties
Published on: May 10, 2018
10.2K
07:47Author Spotlight: An Antimicrobial Fabric Using Nano-Herbal Encapsulation of Essential Oils
Published on: April 7, 2023
7.8K
相关概念视频
01:28Antimicrobial Effectiveness
2
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
2
01:27Combined Effects of Drugs: Synergism
3.7K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.7K