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CD34和Ki-67免疫表达在周围细胞粒瘤中:对血管新生和细胞增殖的影响

Ciprian Roi¹, Mircea Riviș¹, Alexandra Roi²

¹Department of Anesthesiology and Oral Surgery, Multidisciplinary Center for Research, Evaluation, Diagnosis and Therapies in Oral Medicine, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Sq. no. 2, 300041 Timisoara, Romania.

Diagnostics (Basel, Switzerland)

|November 9, 2024

概括

周围细胞粒瘤表现出高基-67和CD34的表达,表明细胞增殖和血管生成的增加. 这表明慢性炎症驱动颗粒组织的生长和发育.

科学领域:

口腔病理学口腔病理学
免疫组织化学免疫组织化学
组织工程是组织工程.

背景情况:

周围牙颗粒瘤的形成是由于牙感染扩散到周围牙骨.
免疫系统试图在这个地方制和消除微生物.
基-67 (细胞增殖) 和CD34 (血管生成) 与炎症透强度相关.

研究的目的:

确定CD34和Ki-67的免疫表达在周围细粒瘤中.
评估它们对颗粒组织生长和发育的影响.
评估核扩散和进化中的角色.

主要方法:

对35个周围细胞粒瘤的组织病理学和免疫组织化学分析.
在拔牙后获得的标本.

主要成果:

在86.5% (32/35) 的病例中,Ki-67反应呈阳性.
发现过度表达Ki-67和CD34.
Ki-67指数与炎症相关的增殖和血管生成.

结论:

持续的炎症会影响基-67和CD34的表达.
观察到持续的生殖能力和异常的血管生成.
第一个评估CD34+和Ki-67+增殖器在周周粒瘤中的研究.

关键词:

CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 CD34 在 Ki-67 机器人血管新生是因为血管新生.细胞的增殖细胞的增殖.颗粒组织颗粒组织周围的细粒细胞瘤.

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