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所谓的临床前类风湿性关节炎:怀疑,挑战和机会

Raimon Sanmartí1, Beatriz Frade-Sosa1, Andres Ponce1

  • 1Arthritis Unit, Rheumatology Department, Hospital Clinic of Barcelona, 08036 Barcelona, Catalonia, Spain.

Journal of clinical medicine
|November 9, 2024
PubMed
概括

本案例研究探讨了潜在的风湿性关节炎早期诊断. 识别前风湿性关节炎对于及时干预和改善患者结果至关重要.

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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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