压力的免疫学:一篇评论文章
1Department of Hematology and Immunology, Faculty of Medicine, Umm Al-Qura University, Makkah 24381, Saudi Arabia.
Journal of clinical medicine
|November 9, 2024
概括
压力严重影响免疫系统,影响疾病易感性. 慢性压力通过下丘脑-垂体-上腺 (HPA) 轴抑制免疫力,需要个性化压力管理策略.
科学领域:
- 神经免疫学 神经免疫学
- 心理神经免疫学 心理神经免疫学
背景情况:
- 压力显著调节免疫系统功能,影响健康和疾病.
- 压力和免疫之间的相互作用涉及影响免疫细胞分布和血液组成的分子和细胞变化.
研究的目的:
- 审查压力和免疫系统之间的复杂关系.
- 探索对健康,疾病预防和个性化压力管理的影响.
主要方法:
- 关于压力和免疫系统相互作用的科学文献的综述.
- 检查下丘脑-垂体-上腺 (HPA) 轴和交感神经系统通路.
- 对将压力与免疫调节联系起来的分子和细胞机制的分析.
主要成果:
- 急性压力可以暂时增强免疫力,而慢性压力会调节或抑制免疫功能.
- 慢性压力通过HPA轴提高皮质醇,导致免疫抑制.
- 个人对压力的免疫反应显示出变异性,由免疫细胞中差异性基因表达表明.
结论:
- 有效的压力管理对于健康和疾病预防至关重要.
- 慢性压力可能与自身免疫性疾病有关,需要进一步研究.
- 由于免疫反应的个体变化,建议采用个性化的压力管理方法.
相关概念视频
What is the Immune System?
Overview
Immune Surveillance by NK Cells and Phagocytes
Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Antigens Involved in Adaptive Immunity
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Cytotoxic T Cells-mediated Immune Response
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immune Response Against Viral Pathogens
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...


