酒精消费对皮肤冠状动脉干预患者心血管事件的影响
Junpil Yun1, Kyungdo Han2, You-Jeong Ki3
1Cardiovascular Center, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Journal of clinical medicine
|November 9, 2024
概括
穿皮冠状动脉干预 (PCI) 后适度饮酒与重大心血管和脑血管不良事件 (MACCE) 的风险降低有关. 与非饮酒者相比,即使饮酒量更高,MACCE风险也较低.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 饮酒对接受皮肤冠状动脉干预 (PCI) 的患者的临床影响尚不清楚.
- 目前对PCI后酒精影响的研究有限,需要进一步研究.
研究的目的:
- 评估PCI后患者的酒精消费模式和临床结果之间的关联.
- 确定不同水平的酒精摄入量是否会影响重大心血管和脑血管不良事件 (MACCE) 的风险.
主要方法:
- 一项全国性的前性研究包括了77,409名接受PCI的患者.
- 根据PCI后的健康检查,患者被分为不饮酒者,标准饮酒者和标准饮酒者.
- 主要不良心血管和脑血管事件 (MACCE) 在4.0年的随访期间被跟踪.
主要成果:
- 在随访期间,整体MACCE发病率为19.7%.
- 在指南范围内饮酒的人 (aHR:0.843) 和超出指南饮酒的人 (aHR:0.829) 与不饮酒的人相比,MACCE风险明显较低.
- 观察到一个J曲线关系,与中度,每周一次的酒精消费 (≤0.33g/kg/周) 相关的最低风险.
结论:
- 饮酒量甚至超过推指南,与PCI后患者不良后果风险降低有关.
- 在PCI前后继续适度饮酒习惯与心血管不良事件的最低风险有关.
- 建议进行进一步的长期研究来验证这些发现.
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