周围和中心胰岛素抵抗在神经精神疾病中的作用

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Kannayiram Alagiakrishnan¹, Tyler Halverson²

¹Department of Medicine, University of Alberta, Edmonton, AB T6G 2R3, Canada.

Journal of clinical medicine

|November 9, 2024

概括

胰岛素抵抗 (IR) 显著影响大脑功能,情绪和认知,导致神经精神疾病,如痴呆和抑郁症. 早期识别和管理IR显示治疗干预的希望.

科学领域:

神经科学是一个神经科学.
代谢障碍代谢障碍代谢障碍
内分泌学在内分泌学.

背景情况:

胰岛素调节大脑中的能量代谢,影响细胞功能.
胰岛素信号传递和胰岛素抵抗 (IR) 对情绪,行为和认知至关重要.
红外线与神经精神疾病的病理生理学有关,包括痴呆症,抑郁症和精神分裂症.

研究的目的:

审查胰岛素和胰岛素受体在健康大脑和神经系统疾病中的作用.
讨论主要神经精神疾病中IR的机制.
探索IR管理在治疗认知和精神疾病方面的潜力.

主要方法:

关于胰岛素信号,红外线和大脑疾病的研究文献综述.
在神经精神疾病中分析IR的病理生理路径和机制.
对量化IR的生物标志物的检查 (例如,HOMA-IR,TyG-BMI).

主要成果:

IR是痴呆症,特别是阿尔茨海默病 (AD) 的重要危险因素,影响发展和进展.
红外线在神经退行之前发生,并且与认知障碍,痴呆症,抑郁症和精神分裂症有关.
像胰岛素水平,HOMA-IR和TyG-BMI这样的生物标志物可以量化IR程度.

结论:

通过改变生活方式和抗糖尿病药物,早期识别和治疗IR,显示了神经精神和认知障碍的治疗潜力.
针对IR的药理学和非药理学方法为管理具有挑战性的脑疾病提供了有希望的策略.
需要进一步的研究来将目前的发现转化为临床实践,以便在神经精神病治疗中有效地管理IR.

关键词:

抗糖尿病药物抗糖尿病药物大脑的胰岛素耐药性痴呆症痴呆症是一种痴呆症.抑郁抑郁症抑郁症抑郁症抑郁症运动就是炼身体.

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