在地中海技术潜水课程后的减压疾病:氧化应激,炎症和HBO疗法
Simona Mrakic-Sposta1,2, Andrea Brizzolari3,4, Alessandra Vezzoli1,3
1Institute of Clinical Physiology, National Research Council (IFC-CNR), Piazza dell'Ospedale Maggiore, 3, 20142 Milan, Italy.
International journal of molecular sciences
|November 9, 2024
概括
潜水可以导致由于压力变化而导致减压疾病 (DCS). 高压氧疗法 (HBOT) 有效地减少与DCS相关的氧化应激和炎症,改善生理反应.
科学领域:
- 潜水医学是一门潜水医学.
- 生物医学科学 生物医学科学
- 生理学 生理学 生理学
背景情况:
- 潜水涉及在上升和下降期间压力变化的风险.
- 减压疾病 (DCS) 由气泡形成而产生的,导致关节疼痛,神经问题和潜在的死亡等症状.
- 立即治疗DCS包括氧气和高压氧气疗法 (HBOT).
研究的目的:
- 在技术潜水之前和之后评估潜水员的氧炎生物标志物.
- 评估DCS和随后的HBOT对这些生物标志物的影响.
- 了解在DCS病例中对HBOT的生理反应.
主要方法:
- 从九名潜水员收集了唾液和尿液样本,用于技术潜水前和后的潜水.
- 测量了氧化应激和炎症的生物标志物.
- 一个DCS病例使用美国海军治疗表接受了HBOT治疗,在治疗前后收集了血液和尿液样本.
主要成果:
- 技术潜水增加了氧化应激 (ROS,脂质过氧化) 和炎症 (互白蛋白,TNFα) 的生物标志物19-126%.
- 氧化代谢物也在潜水后增加了36%.
- 在DCS发作后的HBOT显著降低了脂质过氧化和炎症标志物,表明氧化应激减少.
结论:
- 技术潜水提高了氧炎和氧化代谢的标志物.
- 高压氧气疗法有效缓解DCS诱导的氧化应激和炎症.
- 在减压疾病后,HBOT对生理恢复产生了积极的影响.
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