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燃烧口腔综合征中的小纤维神经病变:系统性审查

Maria Kouri¹, Daniela Adamo², Emmanouil Vardas¹

¹Department of Oral Medicine & Pathology and Hospital Dentistry, School of Dentistry, National and Kapodistrian University of Athens, 15772 Athens, Greece.

International journal of molecular sciences

|November 9, 2024

概括

小纤维神经病变 (SFN) 与口腔炎综合征 (BMS) 密切相关,导致疼痛和感官问题. 研究表明,BMS患者的神经纤维减少和感觉值改变,支持SFN.

科学领域:

神经学神经学
疼痛研究疼痛研究
口腔医学是指口腔医学.

背景情况:

燃烧口腔综合征 (BMS) 是一种原因不明的慢性口腔面部疼痛状况.
小纤维神经病变 (SFN) 越来越多地与神经病痛疾病有关.

研究的目的:

系统地审查和综合有关SFN在BMS病理生理学中的作用的证据.
在BMS患者中评估与SFN相关的诊断标志物和感觉变化.

主要方法:

按照PRISMA指南进行系统的文献搜索.
分析了8项报告舌头活检结果的研究和7项使用定量感官测试 (QST) 的研究.
包括眼反射试验和角膜共焦显微镜的数据.

主要成果:

八项研究报告了BMS患者舌头活检中神经纤维密度的显著减少 (30-60%).
观察到TRPV1,NGF,P2X3纤维的增加,Nav1.7的过度表达,以及Nav1.9mRNA的减少.
QST揭示了感官异常,包括降低了凉爽和寒冷的疼痛值;眼反射和角膜显微镜表明SFN.

结论:

强有力的证据支持SFN作为BMS病理生理学的关键因素,由减少神经密度和改变感官功能证明.
研究结果的变化需要更大规模的标准化研究,以寻找因果关系和治疗开发.

关键词:

导航1.7 在 Nav1.7 中.导航1.9 在线导航这是一个P2X3X3P2X3P.在 TRPV1 中.燃烧口腔综合征是什么意思小纤维神经病变小纤维神经病变

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