结肠直肠癌中的生物标志物:实际和未来的前景
Horia-Dan Lișcu1,2, Nicolae Verga2, Dimitrie-Ionuț Atasiei1
1Discipline of Oncological Radiotherapy and Medical Imaging, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
International journal of molecular sciences
|November 9, 2024
概括
本综述探讨了用于查,诊断和预后的结直肠癌 (CRC) 生物标志物. 液体活检,下一代测序 (NGS) 和人工智能的进步正在增强早期检测和治疗策略.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断学
- 基因组学就是基因组学.
背景情况:
- 结肠直肠癌 (CRC) 生物标志物研究正在迅速发展.
- 目前的查方法在全球范围内各不相同,新兴技术提供了更好的检测.
- 下一代测序 (NGS) 和液体活检技术正在改变CRC诊断.
研究的目的:
- 批判性地审查CRC生物标志物的当前景观.
- 探索有希望的未来生物标志物用于CRC查,诊断和预后.
- 要突出像NGS和AI这样的先进技术对CRC生物标志物发现的影响.
主要方法:
- 对当前和新兴CRC生物标志物的文献综述.
- 分析查技术的进步,如多目标便DNA (mt-sDNA) 和Cologuard Plus.
- 探索新的生物标志物,包括 Galectins,septins,以及肠道微生物组 (例如,Fusobacterium nucleatum) 的样本.
主要成果:
- 多目标便DNA (mt-sDNA) 和Cologuard Plus是著名的查工具.
- 盖लेक्ट因,septin和Fusobacterium nucleatum显示出早期CRC检测的潜力.
- 循环瘤细胞和通过NGS循环DNA分析是有效的诊断和预后工具.
结论:
- CRC生物标志物的领域是充满活力的,在查和诊断方面取得了重大进展.
- 新兴的生物标志物和人工智能等技术对改善CRC患者的治疗结果具有很大的前景.
- 对新型生物标志物的持续研究对于提高早期检测和个性化治疗至关重要.
相关概念视频
01:30Serum Laboratory Studies, Stool Test, Breath Test
316
Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
316
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K