相关实验视频

Updated: Jun 7, 2025

Profiling of Methyltransferases and Other S-adenosyl-L-homocysteine-binding Proteins by Capture Compound Mass Spectrometry CCMS

Profiling of Methyltransferases and Other S-adenosyl-L-homocysteine-binding Proteins by Capture Compound Mass Spectrometry CCMS

Published on: December 20, 2010

对于肝脏健康的S-Adenosylmethionine (SAMe):一个系统性审查

Kyrie Eleyson R Baden¹, Halley McClain¹, Eliya Craig¹

¹School of Pharmacy, Cedarville University, Cedarville, OH 45314, USA.

|November 9, 2024

概括

S-adenosylmethionine (SAMe) 有效地改善肝脏参数,副作用最小. 建议每天服用1000-1200毫克的常见剂量,但需要更多的研究才能在肝脏疾病中得到最佳使用.

科学领域:

肝病学肝病学是一种肝病学.
药理学药理学是指药理学的学科.
系统审查是系统的审查.

背景情况:

S-adenosylmethionine (SAMe) 是一种天然存在的化合物.
在治疗肝功能障碍方面,SAME已经显示出潜力.

研究的目的:

系统地审查SAME在肝脏疾病中的疗效.
评估SAME在肝脏疾病中的安全性.
为了确定肝脏治疗的最佳SAME剂量.

主要方法:

按照PRISMA指南进行系统审查.
在PubMed,CINAHL和Web of Science数据库中进行了搜索.
两个独立的审查员选和提取数据,第三个解决冲突.

主要成果:

从1881年的初始记录中,包括了15项高质量的研究 (评分为4-5/5).
SAMe在提高肝脏相关参数方面表现出有效性.
副作用是罕见的,主要是轻微的胃肠道问题.

结论:

通常使用的剂量是每天1000毫克或1200毫克SAME.
SAMe可以单独使用或与其他治疗一起使用.
需要进一步的研究,以确定长期的疗效,安全性和最佳的施用途径.

关键词:

这是一种S-adenosylmethionine.一样的,同样的,同样的.肝脏肝脏肝脏肝脏肝脏肝脏营养药营养药是一种营养药.

更多相关视频

In Vitro Assay to Measure Phosphatidylethanolamine Methyltransferase Activity

In Vitro Assay to Measure Phosphatidylethanolamine Methyltransferase Activity

Published on: January 5, 2016

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy

Exploring the Arginine Methylome by Nuclear Magnetic Resonance Spectroscopy

Published on: December 16, 2021

相关概念视频

Phase II Reactions: Methylation Reactions

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...

Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation

Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation

Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
Several distinctive characteristics distinguish glutathione conjugation from other phase II...