微生物视角:关于高血压和肠道微生物群的系统文献综述
Alexandros Tsiavos1, Christina Antza1, Christina Trakatelli1
13rd Department of Internal Medicine, Aristotle University, Hypertension-24 h Ambulatory Blood Pressure Monitoring Center, Papageorgiou Hospital, 56429 Thessaloniki, Greece.
Nutrients
|November 9, 2024
概括
高血压患者可能有改变的肠道微生物群,由减少的α多样性和更高的Firmicutes-to-Bacteroidetes比率表明. 需要进一步的研究来证实这些发现,以预防高血压.
科学领域:
- 微生物组研究的研究.
- 心血管健康的心血管健康
- 人类生理学 人类生理学
背景情况:
- 预防高血压需要了解其原因.
- 肠道微生物群 (GM) 与高血压有关,但机制尚不清楚.
- 转基因的α多样性是关键指标.
研究的目的:
- 系统地审查有关肠道微生物群α多样性和高血压的研究.
- 综合当前关于转基因生物与高血压之间关联的证据.
主要方法:
- 在 MEDLINE/PubMed,Scopus 和 EMBASE 的系统文献搜索.
- 包括报告转基因生物与高血压相关的研究.
- 对研究质量的批判性评价.
主要成果:
- 包括18项研究.
- 在高血压患者中观察到较低的香农指数 (α多样性).
- 对于Chao1,Simpson或ACE指数没有发现显著差异.
- 在高血压患者中,始终观察到高 Firmicutes-to-Bacteroidetes (F/B) 比率.
结论:
- 患有高血压的患者可能患有肠道失调,这表明α多样性下降和F/B比率增加.
- 对二次多样性指数的不一致发现需要进一步调查.
- 大规模,精心设计的研究对于阐明转基因在高血压中的作用至关重要.
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