地中海饮食模式:在晚期慢性病中与心血管风险相关的不同改变途径的潜在影响
Jordi Rovira1,2, María José Ramirez-Bajo1,2, Elisenda Bañon-Maneus1,2
1Laboratori Experimental de Nefrologia i Trasplantament (LENIT), Institut d'Investigacions Biomètiques August Pi i Sunyer (IDIBAPS), 08027 Barcelona, Spain.
Nutrients
|November 9, 2024
概括
慢性病 (CKD) 中的心血管疾病 (CVD) 与改变的血清代谢物和蛋白质有关. 地中海饮食可以通过向这些途径,帮助预防CKD患者的心血管疾病.
科学领域:
- 生物化学 生物化学
- 蛋白质组学是指蛋白质组学.
- 代谢学 代谢学 代谢学
背景情况:
- 心血管疾病 (CVD) 是慢性病 (CKD) 患者的主要死亡原因.
- 地中海饮食显示出通过改善内皮功能,炎症,脂质概况和血压来降低心血管疾病风险的潜力.
- 综合代谢和蛋白质组分析可以阐明CKD中尿素诱导的心血管疾病途径,识别那些可以通过饮食修改的.
研究的目的:
- 为了研究晚期慢性病 (aCKD) 中的血清代谢和蛋白质蛋白质概况.
- 确定与aCKD患者心血管疾病风险相关的特定途径和生物标志物.
- 探索潜在的饮食干预措施,如地中海饮食,用于预防CKD中的心血管疾病.
主要方法:
- 来自19名aCKD患者和27名健康志愿者的血清样本进行了代谢和蛋白质组分析.
- 用四种不同的方法量化代谢物;在消耗了七种丰富的血清蛋白质后,分析了蛋白质.
- 综合性分析利用MetaboAnalyst 4.0和STRING 11.0进行途径和生物标记物识别.
主要成果:
- 与对照组相比,aCKD患者的135种代谢物和75种蛋白质的表达有差异.
- 途径分析揭示了先天免疫系统途径 (补充,凝血,中性粒细胞脱粒) 的显著改变,并破坏了酸和胆固醇代谢.
- 关键的改变代谢物和蛋白质包括谷氨过氧化酶3,卡尼丁,homocitrulline,3-methylhistidine和各种氨基酸.
结论:
- 在aCKD中存在血清代谢和蛋白质组的显著失调,与内皮功能障碍和心血管疾病途径有关.
- 这些发现突出了CKD中CVD的潜在治疗点.
- 饮食干预,如地中海饮食,可能为CKD患者的心血管疾病预防提供有益的策略.
相关概念视频
01:22Heart Failure Drugs: Diuretics
345
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
345
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
391
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
391
01:17Factors Affecting Renal Clearance: Renal Impairment
57
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
57
01:18Hypertension and Regulation of Blood Pressure
1.9K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
1.9K
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
60
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
60
01:17Pathophysiology of Heart Failure
1.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.5K