甘功能成分摄入量对血压的影响:通过元分析和NETWORK毒理学进行系统审查
Tianyu Wu1, Jingyi Yang1, Jiayue Xia1
1Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China.
Nutrients
|November 9, 2024
概括
含有糖酸 (GA) 的甘显著增加血压,而甘黄 (LF) 则没有. 在这里,你会看到一条路.
科学领域:
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
- 心血管研究研究心血管研究
背景情况:
- 甘是一种传统的草药,含有各种生物活性化合物.
- 了解甘成分对血压的特定影响对于其安全应用至关重要.
- 来自甘草的功能成分需要彻底调查它们对心血管健康的影响.
研究的目的:
- 为了评估甘的功能成分对血压的影响.
- 阐明甘引起的血压变化背后的作用机制.
- 为甘衍生的功能性食品和个性化营养提供安全数据.
主要方法:
- 在多个数据库 (PubMed,Cochrane,Medline,Embase,EBSCO,ScienceDirect,Web of Science) 进行了系统的搜索.
- 关于甘摄入量的随机对照试验 (RCT) 被纳入了元分析.
- 机器学习,ROC分析,分子对接和GSEA被用来探索机制.
主要成果:
- 对8项RCT (541名参与者) 的分析显示,糖酸 (GA) 显著增加了静缩血压 (SBP) 和静缩血压 (DBP).
- 主要含有甘黄 (LF) 的干预措施没有显著影响SBP或DBP.
- 机器学习将GFI1B,MYLK和RSU1确定为关键生物标志物,GA可能通过代谢途径调节这些生物标志物.
结论:
- 不同的甘成分对血压产生不同的影响.
- 具有GA优势的甘草会增加SBP和DBP,而具有LF优势的甘草则不会.
- GA的高血压机制可能涉及GFI1B,MYLK和RSU1调节的代谢.
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