乳腺癌中心脏毒性的营养调节:一个范围审查
Emma Stephenson1, Marie Mclaughlin1,2, James W Bray1
1School of Sport, Exercise and Rehabilitation Sciences, University of Hull, Hull HU6 7RX, UK.
Nutrients
|November 9, 2024
概括
包括口服补充剂和地中海饮食在内的营养干预措施可以帮助在接受化疗的乳腺癌患者中减少心脏损伤 (心脏毒性). 这些策略在改善心脏功能和减少与治疗有关的心血管并发症方面表现有前途.
科学领域:
- 在瘤学瘤学.
- 心脏病学 心脏病学
- 营养科学 营养科学
背景情况:
- 乳腺癌治疗改善了存活率,但可能导致心脏毒性,其特点是左心室喷射率 (LVEF) 降低和心脏功能障碍.
- 有抗氧化和抗炎性质的口服补充剂可以减轻心脏毒性风险和左心室功能障碍.
- 正在探索营养干预措施来管理化疗诱导的心脏毒性.
研究的目的:
- 审查有关调节乳腺癌患者心脏毒性的营养干预措施的现有证据.
- 评估口服补充剂和饮食策略在管理化疗相关心脏副作用方面的有效性.
- 为未来营养瘤学和心血管健康研究提供见解.
主要方法:
- 使用特定关键字进行了系统的文献搜索.
- 为了选择相关研究,预先确定了包含和排除标准.
- 从符合条件的研究中获得的证据被审查,以综合营养干预和心脏毒性方面的发现.
主要成果:
- 包括七项研究:六项是化学疗法期间口服补充剂,一项是治疗后地中海饮食.
- 在接受营养干预的患者中,五项研究报告了LVEF显著减弱的减少.
- 所有研究都显示了血清心脏生物标志物的显著改善.
结论:
- 营养干预措施,包括口服抗氧化剂补充剂和地中海饮食咨询,可以调节乳腺癌患者的心脏毒性风险.
- 这些干预措施显示出降低与癌症治疗相关的心血管并发症的潜力.
- 进一步的研究可以探索优化营养策略,以改善患者的治疗结果并降低医疗保健成本.
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