炎症状态对调整青少年肠外营养需求的影响
Jéssica Lavanholi Pinho1, Renata Germano Borges de Oliveira Nascimento Freitas1, Tiago Henrique de Souza1
1Department of Pediatrics, School of Medical Science, State University of Campinas (UNICAMP), Campinas 13083-887, Brazil.
定制的亲肠道营养 (PN) 适用于营养不良或炎症的青少年. 在PN中早期的能量蛋白补充可以减少进一步定制的需要,即使C-反应蛋白水平升高.
科学领域:
- 临床营养学 临床营养学
- 儿科胃肠病学 儿科胃肠病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 亲肠道营养 (PN) 可以根据患者的需要进行标准化或个性化.
- 炎症显著影响住院青少年在标准和定制PN之间的选择.
研究的目的:
- 评估炎症对青少年使用标准与定制PN的决定的影响.
- 在这个人群中确定PN定制的关键临床和生化指标.
主要方法:
- 一项历史的队列研究分析了接受PN的61名青少年的数据.
- 在PN的前7天收集了营养,临床和生化数据.
- 评估了炎症状态,并使用了明确的PN定制的具体标准.
主要成果:
- 在128个PN解决方案中,有73个针对40/61名患者进行定制.
- 恢复能量-蛋白质充足度是定制的主要原因 (n=48).
- 早期的能量蛋白补充与更高的跨甲基素水平相关,减少了进一步的定制需求 (r=-0.544,p=0.044).
- 增加的C-反应蛋白水平与PN重新调整正相关 (r=0.509,p=0.044).
结论:
- 患有代谢变化的青少年的营养不良和炎症状态需要定制的PN.
- 早期营养优化可以影响PN疗法调整.
- 炎症在确定青少年PN策略方面发挥着至关重要的作用.
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