心血管风险因素和Transthyretin V142I载体中的遗传风险
Naman S Shetty1, Mokshad Gaonkar2, Akhil Pampana2
1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA.
JACC. Heart failure
|November 9, 2024
概括
良好的心血管风险因子概况降低了黑人患有西V142I变异的心力衰竭风险,但并没有消除它. 管理风险因素对于V142I航母至关重要.
科学领域:
- 心脏病学 心脏病学
- 遗传学 遗传学 是一个
- 公共卫生 公共卫生
背景情况:
- 在美国,黑人人中,V142I变种在3-4%的黑人中流行,增加了心力衰竭的风险.
- 心血管风险因素对V142I载体心力衰竭结果的影响尚不清楚.
研究的目的:
- 为了研究心血管风险因素如何影响携带西V142I变体的个体心力衰竭风险.
主要方法:
- 利用了TOPMed,REGARDS和我们所有人研究计划队伍的数据,包括自认的黑人个人.
- 根据V142I基因型和心血管风险因素的数量 (高血压,糖尿病,肥胖,高胆固醇血症) 分层参与者.
- 员工调整了考克斯模型,以分析心力衰竭与V142I基因型和风险因素概况的关联.
主要成果:
- 对48,365名个人 (1,625名V142I携带者) 的横截面分析显示,根据V142I状态,心血管风险因子患病率没有差异.
- 对18407名个人 (587名V142I携带者) 的纵向分析显示,具有有利 (0-1 RF) 概况 (aHR:2.26) 的心力衰竭风险减弱,而非有利 (3-4 RF) 概况 (aHR:4.14).
结论:
- 良好的心血管风险因素概况显著降低,但不能消除与V142I变体相关的心力衰竭风险.
- 保持良好的心血管风险因素概况对于减轻V142I载体心力衰竭风险很重要.
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