高度自我控制是否加速低收入青少年的表观遗传衰老?
Hyungkyung Kim1, Edith Chen2, Gregory E Miller2
1Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
概括
高度的自我控制可能会加速低收入的有色人种青少年的表观遗传衰老. 然而,强有力的社区支持可以防止这种健康风险,这表明社区资源可以起到温和的作用.
科学领域:
- 表观遗传学和发育心理学.
- 公共卫生和健康的社会决定因素.
背景情况:
- 低收入青少年,特别是有色人种青少年的持续自我控制可能会导致生理成本,增加心脏代谢疾病的风险.
- 表观遗传衰老加速 (EAA) 是一种潜在的机制,将自我控制与心脏代谢健康联系在一起,但其与高自我控制的关联需要进一步研究.
- 在这个人群中,可能会减轻高自我控制对健康的不利影响的保护因素尚未得到充分了解.
研究的目的:
- 评估低收入青少年的自我控制和EAA之间的关联,检查种族和种族的潜在变化.
- 调查邻里集体效能 (NCE) 和学校连接是否能缓和自我控制和EAA之间的关系.
主要方法:
- 利用了来自家庭未来和儿童福祉研究的数据,包括772名低收入青少年 (平均年龄15.6岁).
- 收集了自我报告的自我控制,NCE和学校连接的措施.
- 评估EAA使用表观遗传钟 (Horvath,皮肤和血液,儿科-口腔-表观遗传) 分析唾液样本;统计分析包括多重线性回归和PROCESS分析.
主要成果:
- 在低收入的有色人种青少年中,更高的自我控制与EAA积极相关,特别是通过皮肤和血液时钟估计时.
- 较高的自我控制和EAA之间的这种关联在低收入的有色人种青少年中没有显著的意义,他们报告了更高的NCE.
- 在低收入白人青少年中没有观察到自我控制和EAA之间的显著关联.
结论:
- 这些发现表明,高自我控制可能与低收入的有色人种青少年加速表观遗传衰老有关.
- 支持性社区资源,如社区集体疗效,可以缓冲高自我控制的潜在不良健康后果.
- 旨在加强社区支持系统的干预措施可以在促进弱势青少年群体心脏代谢健康方面发挥重要作用.
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