一项回顾性研究,评估在患者的喘控制在Fluticasone Propionate/Salmeterol主动定期剂量与非控制性喘史的患者
Ahmad Izuanuddin Ismail1, Irfhan Ali Hyder Ali2, Chee Kuan Wong3
1Hospital Al-Sultan Abdullah, Faculty of Medicine, Universiti Teknologi MARA, Shah Alam, Malaysia. izuanuddin@uitm.edu.my.
Pulmonary therapy
|November 9, 2024
概括
将非控制性喘患者转换为常规剂量 (FP/SAL PRD),显著改善了喘控制. 这项现实研究表明,91.7%的患者实现了控制,减少了恶化和缓解药物的使用.
科学领域:
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
- 现实世界的证据研究研究.
背景情况:
- 该MERIT研究评估了马来西亚患有非控制性喘的患者的喘控制.
- 患者从按需要 (pro re nata [PRN]) 布德索尼德/福尔摩特醇或吸入性皮质类固醇 (ICS) 与短效β-激动剂 (SABA) 切换到主动定期剂量的酸/沙米特醇 (FP/SAL PRD).
研究的目的:
- 评估在以前接受PRN疗程的非控制性喘患者中,主动定期给药FP/SAL的有效性.
- 为了评估喘控制的改善,恶化率和缓解药物的使用.
主要方法:
- 使用马来西亚医疗记录进行的回顾性,观察性,多中心研究.
- 分析了120名患有非控制性喘的患者在基线和在升级到FP/SAL PRD后3-6个月的随访.
- 主要终点:喘控制测试 (ACT) 成绩的改善;次要终点:恶化,缓解剂使用,全身皮质类固醇使用,急诊,住院.
主要成果:
- 91.7%的患者实现了喘控制 (p < 0.001),平均ACT得分显著改善 (p < 0.0001).
- 观察到中度/重度恶化,缓解药物,全身皮质类固醇使用,急诊室访问和住院治疗的减少.
- 在随访期间没有报告任何不良事件.
结论:
- 氨酸/沙米特醇主动定期剂量 (FP/SAL PRD) 是一种有效的治疗方法,用于PRN治疗方案中患有失控喘的患者.
- 这一策略改善了喘控制,并减少了恶化和医疗保健资源利用.
相关概念视频
01:30Asthma-IV: Diagnostic and Management
2.5K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.5K
01:20Asthma: Pathogenesis and Management
359
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
359
01:29Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
01:26COPD: Management Using Bronchodilators and Corticosteroids
182
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
182
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
237
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
237
01:25Antiasthma Drugs: β2-Adrenoceptor Agonists
234
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
234