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Updated: Jun 7, 2025

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以结构为导向的亲和/共价键双驱动抑制剂的设计,针对FBPase的AMP部位

Hongxuan Cao1, Zeyue Huang1, Zheng Liu1

  • 1State Key Laboratory of Green Pesticide, College of Chemistry, Central China Normal University, Wuhan 430079, China.

Journal of medicinal chemistry
|November 9, 2024
PubMed
概括

新的双驱动抑制剂向果糖-1,6-双酸酶 (FBPase),这是糖尿病和癌症的关键酶. 与C179的共价结合增强了长期的低血糖效应,提供了一个有前途的药物开发策略.

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