在中国人口中绘制肠道微生物健康衰老的结构变化图
Luqi Shen1, Hui Zhao1, Yue Xi2
1Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China.
Cell reports
|November 9, 2024
概括
在衰老过程中绘制肠道微生物结构变体 (SVs) 地图,揭示了与健康相关的关键变化. 特定的SV区分健康的衰老和连接到饮食和疾病,提供长寿的见解.
科学领域:
- 微生物学 微生物学
- 基因组学就是基因组学.
- 老年学是一门学科.
背景情况:
- 肠道微生物组结构变异 (SVs) 越来越多地被认为对宿主健康的作用.
- 了解人类衰老过程中的微生物群对健康衰老和与年龄相关的疾病的影响至关重要.
研究的目的:
- 在一大批中国参与者中对肠道微生物的特征进行鉴定.
- 为了确定与衰老,健康衰老和与年龄相关的慢性疾病相关的SV.
- 阐明特定的SV,饮食,新陈代谢和衰老结果之间的机制联系.
主要方法:
- 来自3230名中国参与者的肠道微生物群落的全基因组测序.
- 生物信息分析用于识别和量化微生物结构变异 (SV).
- 统计学协会分析将SV与衰老状态,健康范围和疾病表型联系起来.
主要成果:
- 确定了与衰老,健康衰老和与年龄相关的疾病相关的关键肠道微生物SV.
- 观察到与衰老相关的SVs中的副本数损失的模式,其中35个核心SVs始终被检测到.
- 发现了八个SV,可以区分健康和不健康的衰老,不论时间的年龄.
- 在Bifidobacterium pseudocatenulatum中有一种特定的3-kbp删除SV,它参与了植物多糖体的降解,与植物性饮食,胆酸代谢和健康的衰老有关.
- 通过 metionin-homocysteine 途径中的基因将 SVs 与慢性病联系起来.
结论:
- 肠道微生物 SVs 是重要的生物标志物和人类衰老的潜在媒介.
- 饮食模式,特别是植物性饮食,影响与健康衰老相关的SVs.
- 针对特定的微生物 SV 和它们的代谢功能,可能为改善健康和寿命提供新的策略.
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