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Updated: Jun 7, 2025

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发现了第一个选择性和强大的PROTAC降解剂,用于TRIB2伪激酶

Chaowei Wen1, Prathibha R Gajjala2, Yihan Liu3

  • 1International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development, Ministry of Education (MoE) of People's Republic of China, College of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou, 510632, China.

European journal of medicinal chemistry
|November 9, 2024
PubMed
概括

我们开发了用于癌症治疗的新型TRIB2 PROTAC降解剂. 化合物5k有效降解TRIB2蛋白,抑制癌细胞生长,并提供一种新的治疗策略.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.这就是 PROTACs.核武器的扩散蛋白质降解 蛋白质降解伪基因酶是一种假基因酶.在Tribe2中,Tribe2是指Tribe2的一部分.

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