评估沉默基因对对亲属关系测试的影响
Da Yang1, Mei Li Li2, An Qi Wei3
1College of Forensic Medicine, Forensic Science Center, JiNing Medical University, P.R. China.
Forensic science international
|November 9, 2024
概括
短串重复 (STR) 亲属测试中的沉默基因总体上影响很小,尽管在某些情况下影响可能很大. 对密切关系使用调整后的概率比率 (LR_adjust) 可以减轻这些影响.
科学领域:
- 法医遗传学 法医遗传学
- 人口遗传学 人口遗传学
背景情况:
- 短串重复 (STR) 位点对于亲属测试至关重要.
- 初始结合区域突变会导致静音基因,导致未观察到的等位基因并影响基因型的准确性.
研究的目的:
- 通过使用概率比 (LRs) 评估沉默基因对对亲属关系测试的影响.
- 为了比较不同的LR计算方法 (LR_exact,LR_observe,LR_adjust) 在静态基因的存在下.
主要方法:
- 为1,2,3度亲属关系测试制定LR方程.
- 使用Familias和GeneVisa软件对配方进行验证.
- 用GeneVisa模拟对对亲属关系测试的静态基因效应.
主要成果:
- 沉默基因对亲属测试的整体影响是最小的,但在特定情况下可能是显著的.
- 沉默基因的影响随着更远的亲属关系而减少.
- 与相关的个体相比,与无关的个体相比,沉默基因效应减少.
结论:
- 调整后的概率比率 (LR_adjust) 有效地减轻了无声基因在一,二度亲属关系测试中的影响.
- 了解和解释沉默基因对于准确的亲属关系分析很重要.
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