在阿尔茨海默氏症诊断之前和之后因感染而入院
Heli Järvinen1, Anna-Maija Tolppanen2, Sirpa Hartikainen3
1School of Pharmacy, University of Eastern Finland, Kuopio, Finland; Kuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland; Wellbeing Services County of North Savo, Vesanto, Finland.
在阿尔茨海默氏症 (AD) 诊断前1-2年,感染显著增加,并在诊断后保持升高. 积极预防感染对于管理认知障碍和减少阿尔茨海默病患者住院治疗至关重要.
科学领域:
- 神经学 神经学
- 传染病流行病学 传染病流行病学
- 老年病的医生 老年病的医生
背景情况:
- 有限的研究存在于感染率和时间变化相对于阿尔茨海默病 (AD) 诊断.
- 了解AD诊断周围的感染模式对于患者的护理和管理至关重要.
研究的目的:
- 研究患有和没有阿尔茨海默氏病 (AD) 的个体感染的速率和时间变化.
- 在AD诊断之前和之后的五年里,每年分析感染率.
主要方法:
- 一个基于登记的队列研究,利用芬兰的药物使用和阿尔茨海默病队列.
- 参与了70718名被诊断为阿尔茨海默氏症的个人和同等数量的匹配的对比个人.
- 相关疾病,药物和感染相关住院的数据从全国范围的注册表中提取.
主要成果:
- 患有阿兹海默症的半数患者经历了与感染有关的住院治疗,而没有阿兹海默症的患者比例为34%.
- 在AD诊断前1-2年,感染率显著上升.
- 患有阿尔茨海默病的个体在住院和门诊感染访问率较高 (每100人年15人 vs. 9人),诊断后住院日数增加.
结论:
- 在阿尔茨海默病患者中,感染住院率较高可能源于全身炎症,门诊感染管理,妄想和护理人员负担.
- 应将感染预防策略纳入认知障碍综合护理.
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