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不寻常的麻贝类在纽约Cayuga湖中中毒毒素
Zacharias J Smith1, Gregory L Boyer2
1USDA Agricultural Research Service, Hydrology and Remote Sensing Laboratory, 10300 Baltimore Ave, Beltsville, MD, 20705, USA; State University of New York College of Environmental Science and Forestry, Department of Chemistry, 1 Forestry Dr., Syracuse, NY, 13210, USA.
概括
在Cayuga湖的蓝藻细菌繁殖在2017-2018年产生了不寻常的麻贝类毒素 (PSPTs). 先进的分析方法证实了PSPTs,但无法确定它们的结构,这表明新型或未明确的毒素.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 分析化学 分析化学
背景情况:
- 在纽约的凯尤加湖 (Cayuga Lake) 观察到蓝藻细菌的繁殖.
- 性贝类中毒毒素 (PSPTs) 被确定为这些开花期间的主要毒素.
- 之前对菌毒素的研究已经为分析方法建立了理论框架.
研究的目的:
- 为了分析和识别Cayuga湖中存在的毒素,从2017年和2018年开始的蓝藻细菌繁殖.
- 调查使用标准PSPT检测方法获得的不寻常结果.
- 为了确定检测到的毒素是否已知PSPT或潜在的新化合物.
主要方法:
- 高性能液体染色学 (HPLC) 使用化学氧化.
- 受体结合试验 (RBA).
- 与酶相关的免疫吸收试验 (ELISA).
- 液体染色学-并联质谱学 (LC-MS/MS). 液体染色学-并联质谱学 (LC-MS/MS).
主要成果:
- 使用多种分析技术证实了PSPTs的存在.
- 所有采用的方法都产生了非常不寻常的结果,与既定的理论预期不一致.
- 检测到的PSPTs的精确结构无法阐明.
- 这些毒素可能代表不寻常或以前未被阐明的PSPT变体.
结论:
- 卡尤加湖在2017年和2018年经历了产生PSPT的蓝藻细菌的繁殖.
- 标准分析方法产生了异常数据,表明毒素表征存在挑战.
- 该研究表明,湖中可能存在新型或未明确的PSPT,需要进一步调查.
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