根据多omics联合分析,针对性结肠炎的Houttuynia cordata多糖的抗炎机制
Yueqi Hu1, Li Zhou2, Jian Yang2
1National Demonstration Center for Experimental Ethnopharmacology Education, School of Pharmaceutical Sciences, South-Central MinZu University, Wuhan 430074, PR China.
International journal of biological macromolecules
|November 9, 2024
概括
在小鼠性结肠炎模型中,Houttuynia cordata多糖 (HCP) 显示出抗炎作用. 奥米克斯的分析显示,其治疗机制涉及调节关键的代谢途径,这表明治疗性结肠炎的潜力.
科学领域:
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
背景情况:
- 胡皮病 (Huttuynia cordata polysaccharide,简称HCP) 是源自传统中医药,具有已知的抗炎性质.
- 性结肠炎 (UC) 是一种慢性炎症性肠病,需要新的治疗策略.
- HCP是一种酸性异多糖,分子量约为13.38kDa,由七种不同的单糖组成.
研究的目的:
- 在性结肠炎的小鼠模型中阐明HCP治疗效果的潜在作用机制.
- 在UC的背景下,研究HCP对代谢和脂质资料的影响.
- 通过医疗保健专家的治疗来调节的关键代谢途径.
主要方法:
- 提取和描述Houttuynia cordata多糖 (HCP) 的情况.
- 对性结肠炎 (UC) 的小鼠模型的建立.
- 应用非向的代谢和脂质组分析来研究血清和结肠样本.
主要成果:
- 在测试度 (100 mg/kg和300 mg/kg) 的小鼠UC模型中,HCP在测试度 (100 mg/kg和300 mg/kg) 中显示出显著的抗炎活性.
- 代谢分析确定了724种不同的代谢物,突出显示了像酸代谢和脂肪酸生物合成这样的途径.
- 脂质组分析显示了包括α-烯酸,酸代谢和甘油脂代谢在内的途径的显著变化.
结论:
- 通过调节关键的代谢和脂质通路,HCP对性结肠炎具有治疗潜力.
- 已识别的代谢途径为HCP的抗炎机制提供了洞察力.
- 进一步研究HCP在炎症性肠病中的作用是有必要的.
相关概念视频
Drugs for Treatment of Ulcerative Colitis in IBD
120
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
120
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
319
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
319
Inflammatory Bowel Disease I: Ulcerative Colitis
143
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
143
Inflammatory Bowel Disease IV: Pharmacological Management
114
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
114
Inflammatory Response
1.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.9K


