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评估I型干扰素在皮肤肌炎中的评分,系统性审查和元分析

Chiara Castellini¹, Claudia Scotti², Luca Navarini³

¹Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Italy.

Autoimmunity reviews

|November 9, 2024

概括

与健康个体相比,皮肤肌炎 (DM) 患者的I型干扰素 (IFN) 评分在皮肤肌炎 (DM) 患者中升高. 在患有抗黑色素瘤分化相关蛋白5 (MDA5) 自体的DM患者中也观察到更高的得分,这表明疾病严重程度的潜在生物标志物.

科学领域:

类风湿病学类风湿病学
免疫学免疫学免疫学
系统性自身免疫性疾病

背景情况:

皮质肌炎 (DM) 是一种罕见的自身免疫性疾病,导致皮肤皮疹和肌肉衰弱.
患有抗黑色素瘤分化相关蛋白5 (MDA5) 自体的DM患者的一个子集经常呈现严重的表型和不良预后.
正在研究I型干扰素 (IFN) 评分作为严重DM的潜在生物标志物.

研究的目的:

系统地综合有关DM患者和健康对照 (HCs) 之间的I型IFN得分差异的证据.
调查DM患者与没有抗MDA5自身抗体之间的I型IFN得分的差异.

主要方法:

一个系统的审查和对2024年5月之前发表的文献进行元分析.
在 MEDLINE,SCOPUS 和 WEB OF SCIENCE 数据库中进行文献搜索.
包括四项研究,比较DM患者 (含/不含抗MDA5) 和HCs的I型IFN得分.

主要成果:

与HC相比,DM患者的I型IFN得分显著高于DM患者 (SMD = 2.27,p = 0.004).
与没有抗MDA5自身抗体的DM患者相比,具有抗MDA5自身抗体的DM患者的I型IFN得分显著更高 (SMD = 0.88,p = 0.03).
在两种比较中都观察到很高的异质性 (I2 = 96%和I2 = 83%).

结论:

升高的I型IFN得分与皮肤肌炎有关.
特别是在具有抗MDA5自身抗体的DM患者中,I型IFN得分较高.
类型I IFN评分评估是临床分析DM患者的宝贵工具,特别是那些具有抗MDA5抗体的患者.

关键词:

反MDA5抗体的抗体.皮肤肌肉菌性炎 (dermatomyositis) 是一种疾病.一类干扰子得分I型干扰子得分

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