精准医学的黎明在纤维化间歇性肺部疾病中
Theodoros Karampitsakos1, Bochra Tourki1, Jose D Herazo-Maya1
1Division of Pulmonary, Critical Care and Sleep Medicine, Ubben Center for Pulmonary Fibrosis Research, Department of Internal Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL.
Chest
|November 9, 2024
概括
精准医学在纤维化间歇性肺部疾病 (ILD) 中表现有前途,识别生物标志物和内型,以进行个性化治疗. 克服实施挑战是改善患者治疗结果的关键.
科学领域:
- 肺部医学 肺部医学
- 基因组学就是基因组学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 间歇性肺部疾病 (ILDs) 包含各种肺部疾病,其中一些进展到纤维性ILDs.
- 渐进性肺纤维化 (PPF) 是纤维性ILDs的一个具有挑战性的方面,包括异常性肺纤维化 (IPF).
- 预测哪些患者会患上PPF仍然很困难,这阻碍了针对性的治疗.
研究的目的:
- 探索精准医学在识别患有纤维性ILD进展风险的患者中的作用.
- 审查IPF和PPF个性化治疗策略的生物标志物和内型鉴定方面的进展.
- 突出精准医学的潜力,以指导特定患者亚组的抗纤维素治疗.
主要方法:
- 对纤维性ILDs中的生物标志物和内型的最近研究的综述.
- 对患者分层和治疗选择的精准医学方法的分析.
- 鉴定显示在特定内型中有效性的化合物.
主要成果:
- 在纤维性ILD中确定了多种疾病风险,诊断,预后和治疗反应的生物标志物.
- 精准医学已经在纤维性ILD中揭示了不同的内型,使患者能够进行歧视.
- 某些抗纤维素化合物的有效性与特定的患者内型相关,这表明个性化治疗的潜力.
结论:
- 在纤维性ILDs的精密医学方面取得了重大进展,确定了生物标志物和内型.
- 临床实践中的实施面临着基础设施,财务,监管和道德障碍.
- 通过精准医学转向以患者为中心的护理可以显著改善ILD患者的生活质量和生存率.
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