在类风湿手的天子和boutonniere变形
Sandra Pfanner1, Andrea Poggetti1
1Hand Surgery and Reconstructive Microsurgery Unit, Azienda Ospedaliero Universitaria Careggi, Florence, Italy; AOUC - Padiglione 25 CTO Largo Brambilla 3, Florence 50139, Italy.
Hand clinics
|November 9, 2024
概括
风湿性关节炎 (RA) 是一种炎症性自身免疫性疾病,导致关节形和死亡. 生物修饰性抗风湿药物 (bDMARDs) 已经影响了RA患者的骨关节炎.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 整形外科 整形外科 整形外科
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性炎症性自身免疫性疾病,病因不明.
- RA 主要影响腹关节关节,导致显著的死亡率和发病率.
- 这种疾病表现为关节炎,导致关节胀,变形和功能障碍.
研究的目的:
- 描述类风湿性关节炎中关节退化的病理过程.
- 突出RA的各种并发症,包括数字形和死亡率.
- 要注意到生物修饰性抗风湿药物 (bDMARDs) 对RA骨关节炎变化的影响.
主要方法:
- 综述RA病理生理学和临床表现.
- 在RA中分析关节退化的机制.
- 讨论bDMARDs对RA相关性骨关节炎的治疗影响.
主要成果:
- RA 通过突关节炎导致渐进性关节损伤,导致像亚脱,收缩和结症这样的形.
- 数字形是由于内在/外在肌肉,肌和带的损伤造成的.
- 手腕干扰包括囊和肌破裂,以及肌肉收缩造成的手部不对齐.
结论:
- RA 是一种复杂的自身免疫性疾病,导致严重的关节破坏和全身并发症.
- 了解RA的发病因子对于管理其衰弱效应至关重要.
- bDMARDs的出现改变了RA的管理格局,特别是关于骨关节炎的参与.
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