在中国人口中,弱ABO亚组的血清特征的流行率和分布
Zhongying Wang1, Sha Jin1, Jiewei Zheng1
1Blood Group Reference Laboratory, Shanghai Institute of Blood Transfusion, Shanghai Blood Center, Shanghai, China.
Hematology, transfusion and cell therapy
|November 9, 2024
概括
许多弱的ABO亚组在献血中被遗漏. 在中国人群中,这些ABO亚组的真实频率为0.044%,BA.04是最常见的等位基因.
科学领域:
- 血液学 血液学 血液学
- 遗传学 遗传学 是一个
- 人口研究 人口研究
背景情况:
- 弱ABO亚组是血液输血安全的一个已知的挑战.
- 准确的频率数据对于有效的血液储存和捐赠者查至关重要.
研究的目的:
- 确定中国人口中弱ABO亚群的真实流行率.
- 描述不同 ABO 亚组等位体的血清性质.
主要方法:
- 分析了2009年至2017年期间收集的2,945,643个血液样本.
- 使用自动分析仪,标准血清学分析和DNA测序进行确认.
- 通过红细胞凝结强度评估抗原表达.
主要成果:
- ABO亚组的初始检测率为0.031%,遗漏检测率为27.81%.
- 在中国人口中,ABO亚组的真实频率计算为0.044%.
- BA.04,BW.12和BA.02是最常见的遗传变异;BW.03表现出最弱的B抗原表达.
结论:
- 在常规查中,大量的ABO亚组经常被遗漏.
- BA.04被确定为中国人群中占主导地位的 ABO 亚基组等位基因.
- 不同的ABO亚基组等位基因显示可变的ABO抗原表达水平.
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