ASO视觉摘要:SOUND试验对现实世界的影响
Andreas Giannakou1,2,3, Olga Kantor1,2,3, Ko Un Park1,2,3
1Division of Breast Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.
Annals of surgical oncology
|November 9, 2024
概括
对于激素受体阳性,符合SOUND标准的HER2阴性乳腺癌患者,省略哨兵淋巴结活检 (SLNB) 显示了与执行SLNB相似的结果. 这支持对在选定的患者中SLNB遗漏的仔细考虑.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 乳腺癌研究研究 乳腺癌研究
背景情况:
- 哨兵淋巴结活检 (SLNB) 是早期乳腺癌中股分期的标准.
- SOUND试验建议在特定的低风险患者中省略SLNB.
- 需要真实世界的数据来验证这些发现.
研究的目的:
- 为了评估结节疾病负担和瘤结局在现实世界患者HR+HER2-乳腺癌谁满足了声音试验资格标准.
- 将这些结果与最初的SOUND试验的SLNB分支进行比较.
- 评估在这个群体中省略SLNB的可行性.
主要方法:
- 对312名HR+HER2-乳腺癌真实世界患者的回顾性分析.
- 患者符合与SOUND试验相似的资格标准.
- 结节疾病负担和瘤结果 (如复发,存活率) 与历史的SOUND试验SLNB手臂数据的比较.
主要成果:
- 现实世界队列中的节点疾病负担与SOUND试验SLNB手臂相比较.
- 癌症结局,包括复发率和存活率,在现实世界队列和SOUND试验SLNB手臂之间是相似的.
- 在关键结果中没有观察到显著差异,这表明安全性可比.
结论:
- 在经过精心挑选的HR+HER2-符合SOUND标准的乳腺癌患者中,SLNB的省略得到了现实数据的支持.
- 这些发现表明,在这个特定的患者群体中,可以安全地省略SLNB.
- 支持在乳腺癌管理中仔细实施降级策略.
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