在无氧单细胞真核生物体中,一种独特的共生体
Jon Jerlström-Hultqvist1,2, Lucie Gallot-Lavallée3, Dayana E Salas-Leiva3,4
1Department of Cell and Molecular Biology, Uppsala Universitet, Uppsala, Sweden. jon.jerlstrom.hultqvist@icm.uu.se.
Nature communications
|November 9, 2024
概括
研究人员在无氧原生体中发现了独特的共生体,揭示了新的共生结构. 这一发现揭示了宿主-共生体相互作用和膜贩运的演变.
科学领域:
- 微生物学 微生物学
- 进化生物学 进化生物学
- 细胞生物学 细胞生物学
背景情况:
- 细胞和核细胞之间的共生关系是生命进化的基础.
- 在动物,植物和真菌中出现了专门的共生结构.
- 微生物真核生物中的共生结构,最常见的宿主,是研究不足的.
研究的目的:
- 为了研究和描述自由生活的无氧原生体 (Anaeramoeba spp. ) 的情况.
- 了解共生体形成和功能的遗传和结构基础.
- 探索对宿主-共生体相互作用和进化过程的影响.
主要方法:
- 完整的基因组测序和宿主和共生者的转录组学.
- 光在现场杂交 (FISH).
- 使用聚焦离子束扫描电子显微镜 (FIB-SEM) 的3D重建.
主要成果:
- 在Anaeramoeba spp. 中发现了高度结构化的共生体.
- 扩展基因家族的识别,调节膜贩运和体成熟.
- 有广泛的细菌到真核生物横向基因转移的证据.
- 共生生物组织在一个网络中,使其能够与宿主基体进行代谢同.
- 共生生物保持与宿主血的连接,模糊外生和内生共生.
结论:
- 交生体的出现是由宿主基因家族扩张和横向基因转移驱动的.
- 交生体网络促进了交生体与宿主之间的代谢合作.
- 这种共生挑战了对外生态和内生态的传统定义.
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