在患有扩散轴突损伤的患者中异常的动态功能网络连接
Jian Li1,2, Yao Wang1,2, Yuanyuan Wang1,2
1Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Scientific reports
|November 9, 2024
概括
扩散轴突损伤 (DAI) 改变动态大脑连接,影响认知功能. 功能网络连接 (FNC) 的这些变化为DAI提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 认知科学 认知科学
背景情况:
- 扩散轴突损伤 (DAI) 是一种与认知障碍相关的严重创伤性脑损伤.
- 在DAI中潜在的神经认知缺陷的网络机制尚未完全理解.
- 功能连接性改变与DAI病理生理学有关.
研究的目的:
- 研究DAI患者的静态和动态功能网络连接 (FNC) 特性.
- 探索FNC变化与DAI中的认知功能之间的关系.
- 阐明DAI后认知障碍的神经机制.
主要方法:
- 休息状态功能磁共振成像 (fMRI) 数据来自26名DAI患者和27名健康对照.
- 独立组件分析 (ICA) 用于静态网络提取.
- 移动时间窗口分析和k-means集群用于识别动态FNC状态.
主要成果:
- DAI患者表现出改变的动态FNC,具有明显的主导状态 (状态1),其特点是增加了分数时间和平均停留时间,与认知得分 (MMSE) 呈正相关.
- 在所有动态状态中,在DAI患者中观察到功能连接强度的增加,特别是在默认模式和视觉网络中.
- 静态网络间FNC在很大程度上保持稳定,突出显示了动态分析的重要性.
结论:
- 动态FNC及其时间属性在DAI中发生了显著的变化,提供了超越静态连接的互补洞察力.
- 功能性大脑网络中的这些动态变化与DAI的认知障碍有关.
- 这些发现为DAI的神经病理生理学及其认知后果提供了新的视角.
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