相关实验视频

Updated: Jun 7, 2025

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

Portal Vein Injection of Colorectal Cancer Organoids to Study the Liver Metastasis Stroma

Published on: September 3, 2021

VEGF-C传播"向前"的结肠直肠癌转移从肝脏到肺部

Susanna Poghosyan¹, Nicola Frenkel², Lotte van den Bent²

¹Laboratory for Translational Oncology and Department of Surgical Oncology, Division of Imaging and Cancer, University Medical Center Utrecht and Utrecht University, Heidelberglaan 100, 3584CX, Utrecht, The Netherlands. susannapog@gmail.com.

British journal of cancer

|November 9, 2024

概括

血管内皮生长因子 (VEGF) -C驱动结肠癌从肝脏转移到肺部的转移. 向VEGF-C和NOTCH通路可能会抑制结直肠癌的进展.

科学领域:

在瘤学瘤学.
癌症转移癌症转移
分子生物学分子生物学

背景情况:

结肠直肠癌 (CRC) 肺转移机制尚不清楚.
肝转移可能会播种肺转移.

研究的目的:

研究肝淋巴血管在CRC肺转移中的作用.
确定VEGF-C是否驱动肝肺转移.

主要方法:

生成的小鼠肝转移器官过度表达VEGF-C.
在老鼠肝脏中重新植入有机体,以研究瘤生长和转移.
分析了基因表达 (WNT,干细胞标记物,NOTCH) 和途径抑制 (DAPT).

主要成果:

较高的VEGF-C,淋巴细胞增生,以及肺转移的肝转移的入侵.
过度表达VEGF-C促进了淋巴侵入和肺转移的形成.
VEGF-C改变了干细胞标记物表达,并激活了NOTCH通路.
NOTCH抑制部分减少了肺转移和淋巴侵袭.

结论:

在结直肠癌中,VEGF-C促进肝肺转移.
针对VEGF-C/NOTCH通路是CRC的一个潜在的治疗策略.
了解转移驱动因素对于有效的癌症治疗至关重要.

更多相关视频

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues

The Establishment of a Lung Colonization Assay for Circulating Tumor Cell Visualization in Lung Tissues

Published on: June 16, 2018

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Published on: November 30, 2016

相关概念视频

Mitogens and the Cell Cycle

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

Metastasis

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...