"MetaCompare 2.0":对生态和人类健康具有抗性风险的差异性排名
Monjura Afrin Rumi1, Min Oh1,2, Benjamin C Davis3,4
1Department of Computer Science, Virginia Tech, Blacksburg, VA 24060, USA.
FEMS microbiology ecology
|November 9, 2024
概括
MetaCompare 2.0将人类健康和生态风险与抗生素耐药性基因 (ARG) 区分开来. 该工具有助于理解对ARG传播和演变的环境影响,为各种微生物群体提供不同的风险评分.
科学领域:
- 环境微生物学环境微生物学
- 基因组学就是基因组学.
- 公共卫生 公共卫生
背景情况:
- 抗生素耐药性基因 (ARG) 构成重大环境和人类健康风险.
- 量化ARG在不同环境中的传播和演变是具有挑战性的.
- 区分人类健康风险与ARG的生态风险对于有效管理至关重要.
研究的目的:
- 推出MetaCompare 2.0,一个改进的管道来评估抗体风险.
- 区分人类健康的抗体风险和生态抗体风险.
- 提供一个用户友好的网络服务,用于计算和可视化抗体风险评分.
主要方法:
- 分析各种元基因组数据集 (废水,土壤,肠道等). 使用MetaCompare 2.0.0进行比较.
- 对管道的敏感性和稳定性进行评估,以应对测序和组装方法的变化.
- 开发一个公开可用的网络服务,用于抗体风险评估.
主要成果:
- MetaCompare 2.0 在各种环境中成功地区分了人类健康和生态抗体风险.
- 风险得分与人为影响和环境压力相关联.
- 管道性能保持一致,尽管技术参数的变化.
结论:
- "MetaCompare 2.0"提供了一种可靠的方法来评估不同的抗体风险.
- 该工具有助于理解ARG的动态,以应对环境因素.
- 该网络服务促进了抗生素耐药性的更广泛应用和研究.
更多相关视频
06:54Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics
Published on: July 19, 2024
961
16:02Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
2.6K
相关概念视频
Relative Risk
117
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
117
Factors Affecting the Risk of Infection
11.4K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.4K
Biodiversity and Human Values
13.0K
Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.
13.0K
Types of Toxins
1.6K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.6K
