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Updated: Jun 7, 2025

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
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Published on: June 13, 2019

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与DICER1突变相关的初级内肉瘤:病例报告和临床前调查

Hirokuni Honma1,2, Kensuke Tateishi3,4,5, Hiromichi Iwashita6,7

  • 1Department of Neurosurgery, Graduate School of Medicine, Yokohama City University, 3-9 Fukuura, Kanazawa, Yokohama, 2360004, Japan.

Brain tumor pathology
|November 10, 2024
PubMed
概括

这项研究详细介绍了第一个患者衍生异种移植模型,用于患有DICER1突变的儿科原发性内肉瘤 (PIS). 研究结果显示,视网膜酸受体 (RAR) 途径是这种罕见的大脑瘤的潜在治疗标.

关键词:
DICER1 的意思是说.这是PDX PDX.主要的头内肉瘤.网红酸受体信号传递系统

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Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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