在IVF计划中预测活产的预测,这些患者经常出现植入失败
Oleksandra Kozyra1, Mykhailo Medvediev1, Andrea Tinelli2
1Department of Obstetrics and Gynecology Dnipro State Medical University (DSMU), 49044 Dnipro, Ukraine.
European journal of obstetrics, gynecology, and reproductive biology
|November 10, 2024
概括
个性化胚胎移植与植入前遗传检测 (PGT) 结合,显著提高了复发植入失败 (RIF) 的妇女的活产率. 与单独使用PGT相比,这种方法为实现怀孕提供了更有效的策略.
科学领域:
- 生殖医学 生殖医学
- 遗传学 是一个遗传学.
- 不孕症治疗 不孕症治疗
背景情况:
- 重复植入失败 (RIF) 被定义为在植入高质量的胚胎后重复出现失败怀孕的情况.
- 对于不育的患者来说,额外的诊断测试至关重要,以防止在未来的体外受精 (IVF) 尝试中出现类似的结果.
研究的目的:
- 评估个性化胚胎移植的预测价值,以植入窗口研究为指导,结合植入前遗传测试 (PGT) 对经常尝试植入的患者.
主要方法:
- 一项前性队列研究,涉及93名不育妇女.
- 评估患者特征,查指标和试管婴儿周期特征 (胚胎数量,质量,发育阶段) 的预测重要性.
- 统计分析包括中位数,四分位数范围,曼-惠特尼U测试,皮尔森的千平方测试和逻辑回归.
主要成果:
- 在RIF患者中,将个性化胚胎移植与PGT结合起来,显著增加了活产概率的3.4倍 (p=0.026).
- 仅PGT就导致活产儿数增加了1.5倍,但这在统计学上并不显著 (p=0.439).
- 开发了RIF患者活产的预测模型,包括PGT-A胚胎的使用,定制的子宫内膜制备以及二次不孕症和男性因子等因素.
结论:
- 确定精确的植入窗口 (IW) 和对胚胎进行PGT是实现RIF患者活产的有效策略.
关键词:
胚胎内膜组织的电子显微镜,形化.宫内膜的受体性 宫内膜的受体性植入失败可能是植入失败.皮佩尔活检是皮佩尔的活检.植入前遗传检测 (PGT) 是一种基因检测.植入窗口 (IW) 是一个植入窗口.下一代测序 (NGS),体外受精 (IVF),胚胎移植 (ET) 等.更多相关视频
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