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聚合诱导的基于排放的光热剂,用于对抗伤口部位的细菌感染:一篇综述

Zhurun Fang¹, Shixuan Zhang¹, Wentao Wang²

¹Jiangsu Province Engineering Research Center of Stomatological Translational Medicine, State Key Laboratory Cultivation Base of Research, Prevention, and Treatment for Oral Diseases, Nanjing Medical University, Nanjing, 210029, China.

|November 10, 2024

概括

新型聚合诱导排放发光剂 (AIEgens) 为治疗慢性伤口感染提供了有希望的非抗生素方法. 这些材料有效地使用光热和光动力学疗法对抗多药耐药细菌.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
伤口治愈研究研究伤口治愈研究

背景情况:

慢性伤口感染对全球健康构成重大挑战,因抗生素耐药性增加而加剧.
传统的抗生素治疗对抗多药耐药细菌的效果越来越差.
迫切需要非抗生素策略来有效治疗感染的慢性伤口.

研究的目的:

审查聚合诱导排放光原体 (AIEgens) 在治疗细菌感染慢性伤口的非抗生素策略中的应用.
突出基于AIEgen的光热疗法 (PTT) 和光动力疗法 (PDT) 在伤口愈合方面的潜力.
讨论AIEgens如何克服传统光疗剂的局限性.

主要方法:

对基于AIEgen的创伤愈合材料现有文献的综述.
通过AIEgens调解使用PTT和PDT的研究分析.
检查AIEgen属性,如聚合诱导的排放,ROS生成和热量产生.

主要成果:

艾因基因克服了传统光热和光敏感剂中常见的聚合诱导的火效应.
艾因基因表现出增强的光稳定性和高效的反应性氧物种 (ROS) 和热量的产生.
基于AIEgen的PTT和PDT表现出强大的抗菌活性,并促进慢性伤口愈合.

结论:

基于AIEgen的材料代表了开发慢性伤口感染有效的非抗生素治疗方法的重大进展.
艾因基因的独特特性使其非常适合用于创伤管理中的先进光疗应用.
对基于AIEgen的治疗方法的进一步研究对治疗复杂的伤口感染的临床转化有很大的前景.

关键词:

聚合诱导的排放发光剂细菌感染是一种细菌感染.光动力学疗法是一种光动力学疗法.光热疗法是一种光热疗法.伤口愈合伤口愈合

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