在精神分裂症中对比度的取决于方向的上下文调制
Victor J Pokorny1, Scott R Sponheim2, Cheryl A Olman1
1University of Minnesota, Department of Psychology, United States of America.
Schizophrenia research
|November 10, 2024
概括
精神分裂症患者在初级视觉皮层 (V1) 中表现出取决于方向的上下文调制,这与之前的预期相反. 这一发现表明空间注意力和图形背景机制影响精神分裂症的视觉处理.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一种精神病学.
- 视觉感知 视觉感知 视觉感知
背景情况:
- 精神分裂症与视觉对比感知障碍有关,通常归因于初级视觉皮层 (V1) 中神经活动的改变.
- 以前的研究表明,精神分裂症患者在V1中的上下文调制被削弱.
研究的目的:
- 用高场fMRI研究精神分裂症患者初级视觉皮层 (V1) 中非典型的上下文调制机制.
- 评估V1内在因素和V1外在因素对视觉处理发生变化的影响.
主要方法:
- 在精神分裂症 (n=34),双相情感障碍 (n=25),亲属 (n=33) 和对照 (n=23) 个体中检查了BOLD反应.
- 利用了一项新的任务,在不同的方向 (20°和70°) 上呈现近距离和远距离周围的格子.
主要成果:
- 在精神分裂症和对照组中观察到V1 BOLD激活的重要取决于方向的上下文调制.
- 发现调制的方向与预测相反,预计抑制的激活增加.
结论:
- 与之前的报道相反,在精神分裂症患者中观察到V1激活的方向依赖调节.
- 空间注意力和图形-地面调制机制可能会显著影响V1.1中观察到的取决于方向的调制.
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