维生素D和多发性硬化症中的心血管结果
Madeleine France-Ratcliffe1, Stephanie L Harrison2, Leona A Verma3
1Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; Cardiovascular Health Sciences, Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool L3 5UX, United Kingdom.
Multiple sclerosis and related disorders
|November 10, 2024
概括
多发性硬化症 (pwMS) 患者的维生素D (25(OH) D水平较低,与较高的心血管疾病 (CVD) 风险有关. 补充胆结石醇似乎没有降低这种增加的风险.
科学领域:
- 神经学 神经学
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
背景情况:
- 维生素D (25(OH) D) 缺乏是一般人群中心血管疾病 (CVD) 的已知危险因素.
- 在患有多发性硬化症 (pwMS) 的人群中,25...OH) D水平与心血管疾病结局之间的关联以前没有被探索过.
研究的目的:
- 为了研究25(OH) D水平与 pwMS.中的长期心血管疾病结局之间的关系.
- 评估维生素D补充剂对该人群中心血管疾病风险的影响.
主要方法:
- 一项观察性队列研究利用了来自70个医疗机构的匿名医疗记录,在pwMS的5年 (2019-2024) 后进行了观察.
- 倾向性得分匹配 (1:1) 用于将pwMS与缺乏/不足的25OH) D水平与具有足够水平的pwMS进行比较,控制人口统计,并发症和心血管护理.
- 考克斯比例危险模型用于分析主要心血管不良事件 (MACE) 的发生率,包括死亡率,中风,心肌梗塞,心力衰竭,心痛和心房动/动.
主要成果:
- 在74372个pwMS中,9%的pwMS含量不足,18%的pwMS含量不足,73%的pwMS含量充足.
- 与适当水平相比,缺乏和不足的25 ((OH) D水平与MACE (HR分别为1.32和1.29) 的显著增加率有关.
- 在pwMS中缺乏或不充分的25 ((OH) D水平的胆卡尔西醇补充剂与没有服用补充剂的适当水平的人相比,没有减轻心血管疾病风险的增加.
结论:
- 在pwMS中缺乏或不充分的25(OH) D水平与MACE的风险增加有关.
- 维生素D补充剂 (胆卡西费醇) 可能无法有效降低低25(OH) D水平的pwMS中心血管疾病风险的增加.
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