在性结肠炎中的建筑隐形扭曲:重新评估的时间
Carlos A Rubio1, Corinna Lang-Schwarz2, Michael Vieth2
1Department of Oncology and Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden.
Journal of gastroenterology and hepatology
|November 10, 2024
概括
建筑密码扭曲 (ACD) 是诊断性结肠炎 (UC) 的关键. 本综述详细介绍了各种加密表型,这些表型有助于ACD,帮助病理学家解释诊断UC活检.
科学领域:
- 胃肠病学 胃肠病学
- 组织病理学 组织病理学
- 炎症性肠道疾病是什么
背景情况:
- 慢性粘膜炎和建筑隐形扭曲 (ACD) 是诊断性结肠炎 (UC) 的关键.
- ACD通常被定义为有不规则排列,扩展,分支和缩短的密室,密室间距离不均.
- 之前的研究表明,诊断性UC活检通常是交叉切断的,这在ACD评估中通常不考虑的因素.
研究的目的:
- 审查和定义 UC 中 ACD 概念所涵盖的各种密码表型.
- 突出考虑密码表型和切割模式在UC组织学诊断中的重要性.
- 增强对跨切片UC活检段中ACD解释的理解.
主要方法:
- 审查现有的文献和定义的性结肠炎的建筑密码扭曲.
- 在UC组织学中观察到的各种密码表型的分类和描述.
- 对交叉切割对密码形态学解释的影响的分析.
主要成果:
- 在UC中,ACD包括各种密码表型,如不对称的分支,密码环,横向芽,'亲吻密码',密码中的密码和侧面定向的密码.
- 在特定领域的不规则形状和大小的密室也为ACD概念做出了贡献.
- 识别这些多样化的表型对于准确解释交叉切割UC活检切片至关重要.
结论:
- 意识到有助于ACD的不同密码表型,可以改善UC组织学的解释.
- 这种理解为病理学家在UC诊断部分评估密码扭曲提供了新的视角.
- 这些发现旨在提高诊断准确度和对性结肠炎中ACD的临床理解.
相关概念视频
01:17Chronic Bowel Disorders: Introduction
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
01:21Inflammatory Bowel Disease V: Surgical Management
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
01:20Inflammatory Bowel Disease II: Ulcerative Colitis
Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
01:25Inflammatory Bowel Disease III: Crohn's Disease
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...