编辑的选择 - 每日远程缺血预先条件为间歇性听:一个虚假的受控随机试验
Kadri Eerik1, Teele Kasepalu2, Holger Post3
1Endothelial Research Centre, University of Tartu, Tartu, Estonia; Department of Surgery, Institute of Clinical Medicine, University of Tartu, Tartu, Estonia; Heart Clinic, Tartu University Hospital, Tartu, Estonia.
概括
远程缺血预调 (RIPC) 在患有外周动脉疾病的患者中没有显著改善步行距离或音症状. 需要进一步的研究来探索RIPC.
科学领域:
- 心血管医学 心血管医学
- 运动生理学 运动生理学
- 再生医学是一种再生医学.
背景情况:
- 远程缺血性预制 (RIPC) 是一种非侵入性方法,涉及短暂的缺血/再输液,以增强组织抵抗力.
- 在患有外周动脉疾病的患者中,RIPC显示了改善骨肌肉功能和运动的潜力.
- 间歇性音 (IC) 显著损害了受影响个体的流动性和生活质量.
研究的目的:
- 为了评估连续28天的RIPC在改善间歇性关节障碍 (IC) 症状方面的疗效.
- 为了比较RIPC与虚假干预对步行距离和相关结果的影响.
主要方法:
- 进行了一项单中心,并行,随机,假控制,双盲试验.
- 42名患有稳定的IC (丰田IIa或IIb阶段) 的患者被随机分配给RIPC或假药治疗28天.
- 主要结局:通过跑步机测试改变最大步行距离 (MWD);次要结局:间歇性音距离 (ICD),音缓解时间 (TRC) 和与健康相关的生活质量 (HRQoL).
主要成果:
- 分析了41名男性患者 (RIPC=23,sham=18) 的年龄为64.9±7.4岁.
- 在14名RIPC患者和8名假患者 (p=0.35) 中观察到MWD的临床显著 (>10%) 改善.
- 在RIPC和虚假组之间,ICD,TRC或HRQoL的变化没有发现统计学上显著的差异.
结论:
- 与假冒干预相比,远程缺血性预调 (RIPC) 在改善MWD,ICD或TRC方面没有显著的好处.
- 这些发现表明,在这种患者群体中,RIPC可能不是一种有效的策略来管理间歇性关节症症状.
- 需要进一步的研究,以探索潜在的替代方案或患者子组,以确定RIPC的有效性.
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