患有癌症患者的糖尿病酸性和高血糖性超大综合征:一个多中心研究
Rabia K Shahid1, Qasem Haider2, Sunil Yadav3
1Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Clinical medicine (London, England)
|November 10, 2024
概括
糖尿病酸性酸症 (DKA) 和高血糖性超综合征 (HHS) 在癌症患者中罕见但严重. 晚期癌症显著增加了这些糖尿病并发症的死亡风险.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 内部医学 内部医学
背景情况:
- 糖尿病酸性酸症 (DKA) 和高血糖性超性综合征 (HHS) 是糖尿病的严重并发症.
- 关于癌症患者的DKA/HHS存在有限的数据.
研究的目的:
- 调查DKA/HHS入院的癌症患者的特征和结果.
- 为了确定与这群人群中医院死亡率相关的因素.
主要方法:
- 在加拿大萨斯卡通 (DKA或HHS) 住院的成年癌症患者的回顾性评估 (2008-2020).
- 单变量逻辑回归分析,以评估临床变量与医院死亡率之间的相关性.
主要成果:
- 33名患有癌症和DKA/HHS的患者 (0.5%) 在6,555名糖尿病和癌症患者中被确定.
- 在36%的病例中,DKA/HHS呈现为新发糖尿病; 73%的病例患有晚期癌症.
- 晚期癌症患者的住院死亡率为42%,早期癌症患者为0% (p=0.032).
结论:
- DKA/HHS在癌症患者中不常见,但在约三分之一的患者中意味着未被诊断的糖尿病.
- 在患有DKA/HHS的患者中,晚期癌症与高的医院死亡率有关.
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