基于烯的深溶解剂和固体微针对不同脂性药物的皮肤透效应进行比较
Grzegorz S Czyrski1, Mikkel K Frese Hjort1, Thomas Rades1
1LEO Foundation Center for Cutaneous Drug Delivery, Department of Pharmacy, University of Copenhagen, 2100 Copenhagen, Denmark.
概括
深度浸泡溶剂 (DES) 和微针 (MNs) 增强皮肤药物透,但有效性取决于药物的脂性. 将DES和MN结合起来,与单个方法相比,没有任何额外的好处.
科学领域:
- 制药科学 制药科学
- 皮肤病学 皮肤病学
- 材料科学 材料科学 材料科学
背景情况:
- 角层是通过皮肤递送药物的主要障碍.
- 化学增强剂,如深度浸泡溶剂 (DES) 和物理方法,如微针 (MNs),可以克服这一障碍.
- 没有直接比较DESs和MNs用于通过皮肤输送.
研究的目的:
- 系统地比较DES和MN在增强通过皮肤透药物的有效性.
- 调查药物脂性对DES和MNs有效性的影响.
- 评估DES和MN对药物透的综合作用.
主要方法:
- 使用基于的DES (薄荷醇和薄荷醇混合物) 和固体微针 (MNs) 来修改皮肤屏障.
- 评估了具有不同脂友性药物的通过皮肤透性:美特罗尼达 (水友性),利多卡因 (中度脂友性) 和克洛特里马 (高度脂友性).
- 使用DES,MNs,两者或对照车辆进行药物透率的比较.
主要成果:
- 无论是DES还是MNs,都会损害皮肤屏障功能,增加药物透.
- 对于水友性药物 (美特罗尼达) 来说,DESs最有效.
- 对于高脂性药物 (克洛特里马) 来说,MNs更有效.
- 两种方法都没有显著改善利多卡因透.
- 与单个策略相比,DES和MN的结合并没有产生更高的透率.
结论:
- 无论是DES还是MNs都是增强通过皮肤递送药物的可行策略.
- 在DES和MNs之间进行选择时,应以药物的脂友性为指导.
- 将DES和MN结合起来,对于通过皮肤透来说没有协同效应的优势.
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